Come across this useful post on reddit

Summary:

• use homebrew for installing/managing mysql/nginx/apache/etc – but not Python!
• use pythonbrew for managing your Python installs.
• use buildout in place of virtualenv. Trust me on this. You will thank me later.
• use supervisor to run any dev-based daemons (nginx/mysql/mongodb/etc).

A main problem I had before is building scipy. Hopefully pythonbrew might fix this issue.